Axiom™ Biobank Genotyping Array, 96 array plate

Catalog number: 902186

The Axiom™ Biobank Genotyping Solution is a widely adopted platform for large-scale biobank genotyping studies. Many of the world’s largest population genetic epidemiology projects have chosen Affymetrix products for their genotyping studies. Axiom Biobank Genotyping Arrays include pre-designed and custom arrays.  Custom arrays use a modular content for rapid design and customization of genotyping arrays to meet your study needs.  The content modules exist within the Axiom™ Genomic Database of over 26 million SNPs and insertion-deletions (indels).  These modules can be combined into an array design, and each module can be modified by adding, removing, or replacing content.

Description:

The Axiom™ Biobank Genotyping Array was designed by and for thought leaders in the human genetics community for high-throughput, high-value genotyping of large sample cohorts to explore the genetics of complex diseases and translational research with a single comprehensive low-cost solution. This array contains one 96-array plate that allows for genome-wide genotyping of large sample collections such as those screened at biobanks, genome centers, and core labs. 

GWAS

• Intelligent marker selection enables imputation of millions of additional SNPs

• The genomic content module of each array is optimized for specific populations and is customizable to any 1000 Genomes population study by adding additional markers of your choosing

• Immune function, including content covering the major histocompatibility complex (MHC), human leukocyte antigen (HLA), and killer-cell immunoglobulin-like receptors (KIR)

Pharmacogenomic markers

• Markers were selected to represent phases of absorption, distribution, metabolism, and excretion (ADME)

Inflammation and HLA

• Contains markers with evidence for association with autoimmune and inflammation

• Covers variants in genes in the HLA and KIR regions known to be important in immune response

Exome

• Rare, non-synonymous coding SNPs and indels in protein coding regions of the genome

• A majority of variants are rare with minor allele frequency (MAF) <1%

• Newly discovered loss-of-function content

• SNPs and indels identified from a sequencing initiative of 26,000 individuals

• Known disease-causing mutations

eQTLs

• Markers that have known associations to RNA expression traits

• Captures unique eQTLs contained in the NCBI Genotype-Tissue Expression (GTEx) eQTL database, GEUVIDAS project, and several other discovery projects

Human disease

• Blood phenotypes

• Cancer common variants

• Cardiometabolic

Choose your content

• Order the pre-designed array and customize it with markers of your choice

• Custom markers may be de novo or selected from the Axiom Genomic Database of genotype-tested markers

Specifications: